SPRAVATO™ (esketamine)

SPRAVATO™ (esketamine) is an FDA-approved treatment for adults with treatment-resistant depression and Major Depressive Disorder (MDD). This innovative therapy is administered as a nasal spray in a certified medical setting under the supervision of a healthcare provider.

Unlike traditional antidepressants that may take weeks or months to show results, SPRAVATO™ may begin relieving depressive symptoms within hours or days for some patients—making it an important option for individuals who have not responded to standard medications.

What Is SPRAVATO™?

SPRAVATO™ is a prescription esketamine nasal spray used in combination with an oral antidepressant. It is specifically approved for patients who have not experienced adequate improvement with other depression treatments. Traditional antidepressants primarily work by increasing levels of neurotransmitters such as serotonin, dopamine, and norepinephrine. SPRAVATO™, however, works differently by targeting the glutamate system, a key pathway involved in mood regulation, cognition, and neural connectivity. By supporting healthier communication between brain cells, SPRAVATO™ may help reduce symptoms of depression and improve overall emotional functioning—especially in cases where other treatments have been ineffective.

Who May Benefit From SPRAVATO™?

SPRAVATO™ may be an appropriate treatment option for adults who:

• Have treatment-resistant depression
• Have been diagnosed with Major Depressive Disorder
• Have not responded to multiple antidepressant medications
• Are seeking an alternative to standard oral antidepressants

All SPRAVATO™ treatments are provided in a monitored clinical setting to ensure safety and effectiveness.

• No anesthesia required
• Most patients experience little to no side effects
• Some individuals may report mild fatigue or headaches, which are typically temporary

What to Expect After Spravato Treatment:

After receiving SPRAVATO® (esketamine) treatment, patients remain in the clinic for at least two hours so a healthcare provider can monitor for side effects and ensure safety. This observation period is required due to the medication’s short-term effects.

Immediately After Treatment

Some patients may experience temporary effects, which can include:

• Drowsiness or fatigue
• Dizziness or lightheadedness
• Dissociation (feeling detached or “spacey”)
• Nausea
• Changes in perception or focus
• Mild increase in blood pressure